Same blue dye in M&Ms linked to reducing spine injury - CNN.com: "The same blue food dye found in M&Ms and Gatorade could be used to reduce damage caused by spine injuries, offering a better chance of recovery, according to new research."
Rats injected with BBG not only regained their mobility but temporarily turned blue.
1 of 2 Researchers at the University of Rochester Medical Center found that when they injected the compound Brilliant Blue G (BBG) into rats suffering spinal cord injuries, the rodents were able to walk again, albeit with a limp.
The only side effect was that the treated mice temporarily turned blue.
The results of the study, published in the 'Proceedings of the National Academy of Sciences,' build on research conducted by the same center five years ago. In August 2004, scientists revealed how Adenosine triphosphate, which is known as ATP and described as the 'energy currency of life,' surges to the spinal cord soon after injury occurs. Researchers found that the sudden influx of ATP killed off healthy cells, making the initial injury far worse. But when they injected oxidized ATP into the injury, it was found to block the effect of ATP, allowing the injured rats to recover and walk again."
Back in 2004, Nedergaard's team discovered that the spinal cord was rich in a molecule called P2X7, which is also known as "the death receptor" for its ability to allow ATP to latch onto motor neurons and send the signals which eventually kill them.
Nedergaard knew that BBG could thwart the function of P2X7, and its similarity to a blue food dye approved by the Food and Drug Administration (FDA) in 1982 gave her the confidence to test it intravenously.
It worked. The rats given BBG immediately after their injury could walk again with a limp. Those that didn't receive a dose never regained their mobility.
Nedergaard told CNN that there is currently no standard treatment for patients with spinal injury when they reach the hospital emergency room.
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