Saturday, September 27, 2008

Hmmh. I think we might want to change the name... but I might be wrong. Compound 5 seems lilke you might "apply it directly.." It might show up in


the salad section at your local grocery store... next to the watermelon.



The soft green heart-shaped leaf of the horny goat weed could hold the key to a new drug for treating erectile dysfunction.

FD: It is herb... http://www.herbalremedies.com/horgoatweed6.html

http://en.wikipedia.org/wiki/Epimedium

Researchers say the Viagra alternative could be as effective as the famous blue pill, but have fewer side-effects.

Mario Dell'Agli of the University of Milan, Italy, and colleagues tested four plants which are used as natural aphrodisiacs in traditional cultures to establish their potential as alternatives to Viagra. Viagra's active compound, sildenafil, works by inhibiting an enzyme called phosphodiesterase-5 (PDE5). Because PDE5 helps control blood flow to the penis, inhibiting PDE5 promotes male erection.

Dell'Agli and his colleagues tested the four plants in vitro to see how efficient they were at inhibiting PDE5. Just one – Epimedium brevicornum, also known as horny goat weed and Bishop's Hat – had an effect. This confirmed previous studies showing that icariin, a compound found inside the horny goat weed, is a PDE5 inhibitor.


Sildenafil, however, is 80 times more effective at inhibiting PDE5 than icariin. Dell'Agli and his team extracted icariin from the plants, and produced six modified versions of it, which they also tested on PDE5. The most efficient of these, compound 5, "works as well as Viagra", says Dell'Agli. A drug made from compound 5 could also cause fewer side effects than Viagra.
In addition to PDE5, sildenafil affects other phosphodiesterases, including some that are essential to sight and heart function. As a result, people who have heart problems are not advised to take Viagra and patients who do take the drug sometimes suffer disturbances to their eyesight.

Preliminary tests suggest that compound 5 does not affect other phosphodiesterases, meaning it may not have the same side effects as Viagra. Compound 5 will now have to go through lengthy clinical trials before it can be approved as a drug. It could be 10 years before it reaches the market.

In the meantime, "if people eat horny goat weed, I think it can be beneficial because it contains icariin," says Dell'Agli. "But it will not be as effective as Viagra." Horny goat weed is found in the wild in China, Asia and Europe.

The research was supported by private funds, but Dell'Agli declined to provide details.
Journal reference: Journal of Natural Products, DOI: 10.1021/np800049y

Like it when a man ages well... love his products.












Legendary Actor Paul Newman Dies
JOHN CHRISTOFFERSEN,
AP

WESTPORT, Conn. (Sept. 27) - Paul Newman, the Oscar-winning superstar who personified cool as the anti-hero of such films as "Hud," "Cool Hand Luke" and "The Color of Money" — followed by a second act as an activist, race car driver and popcorn impresario — has died. He was 83.
Newman died Friday at his farmhouse near Westport following a long battle with cancer, publicist Jeff Sanderson said. He was surrounded by his family and close friends.

Sounds like they debated. I was working late and recorded it on the DVR...

Mr. Obama sought to undercut his opponents’ extra decades on the world stage by painting him as dangerously hawkish, while Mr. McCain questioned the Democrat’s basic understanding of how and when to wield troops and diplomacy.

“The next president of the United States is not going to have to address the issue as to whether we went into Iraq or not,” Mr. McCain said. “The next president of the United States is going to have to decide how we leave, when we leave, and what we leave behind.”
Mr. Obama lauded the strides U.S. troops have made in Iraq since the surge Mr. McCain pushed for but said, “that was a tactic designed to contain the damage of the previous four years of mismanagement of this war. John, you like to pretend like the war started in 2007. …When the war started, you said it was going to be quick and easy.”
Mr. McCain retorted with condescension, saying, “I’m afraid that Sen. Obama doesn’t understand the difference between a tactic and a strategy.”
Foreign policy was the planned focus of the 90-minute debate at the University of Mississippi. But with Wall Street on the brink of meltdown, talk of nuclear proliferation, Russian aggression in Georgia, China’s growing clout, and threats from Iran and North Korea consumed only about half the time.
Moderator Jim Lehrer of PBS made sure of that, moving straight to the financial crisis that almost kept Mr. McCain from coming. He probed for specifics on how the candidates would bail out the markets, and prodded the senators to engage each other directly on that and other topics — yielding one of the livelier debates in years.
Mr. McCain shrugged off speculation that he might not vote for whatever bailout plan emerges from Congress, to prove his bona fides as a maverick and distance himself from President Bush.
“Sure,” he said, when asked if he’ll support the eventual plan.
Televised debates have been a fixture of presidential campaigns since John F. Kennedy and Richard Nixon met in 1960.
Viewership for this debate could hit a record 100 million. But it almost didn’t happen. Mr. McCain dropped a bombshell Wednesday afternoon by threatening a boycott until Congress and White House hammered out a bailout for Wall Street. He didn’t relent until late Friday morning, after an extraordinary White House summit Thursday with Mr. Bush, Mr. Obama and congressional leaders ended without a deal.
Democrats accused him of injecting presidential politics into the talks and setting back progress. But after the debate, the campaign said Mr. McCain was returning to Washington to keep pushing for a breakthrough.
Mr. Obama tried to paint the Republican not as an agent of change but as a champion of policies that led to the crisis — “a theory that basically says that we can shred regulations and consumer protections and give more and more to the most, and somehow prosperity will trickle down. It hasn’t worked.”
Mr. McCain refused to take the blame. “A lot of us saw this train wreck coming,” he said.
Both agreed that the massive bailout will put a huge crimp on their budget priorities as president.
Mr. McCain proposed to freeze spending on everything other than defense, veterans and entitlement programs.
Mr. Obama derided that as simplistic. “The problem with a spending freeze is you’re using a hatchet where you need a scalpel,” he said.
As the relative newcomer, Mr. Obama’s challenge was to present himself as a plausible commander-in-chief. Mr. McCain missed few openings to undercut that effort, ticking off names of world leaders he’s met with and hotspots he’s visited.
He attacked Mr. Obama’s willingness to meet with Iran’s leaders, noting that President Mahmoud Ahmadinejad has called Israel “stinking corpse.” Such a meeting, he said, “isn’t just naive; it’s dangerous.”
He also accused Mr. Obama of “naïveté” when Russia invaded Georgia, by calling on restraint from both sides when Russia was clearly the aggressor — loaded language clearly meant to cast doubt on the Democrat’s readiness to lead.
Mr. Obama responded with derision of his own, noting that former Secretary of State Henry Kissinger — a longtime McCain friend and sometime adviser — has agreed on the advisability of meeting with adversaries like Iran.
And he poked Mr. McCain for refusing recently to commit to a meeting with Spain’s new president — though Mr. Obama slipped and referred to the prime minister.
“I mean, Spain? Spain is a NATO ally,” Mr. Obama said. “If we can’t meet with our friends, I don’t know how we’re going to lead the world in terms of dealing with critical issues like terrorism.”
Mr. McCain slipped a few times himself, rushing through some of his stock lines so fast he mangled them.
His oft-told joke about $3 million spent studying the DNA of bears in Montana fell flat with a punch line about whether that was a criminal or “paternal” case (he meant paternity). His tough talk on pork-barrel spending came out as a threat to block every federal outlay. “I’ve got a pen,” he said, gesturing with his Sharpie, “and I’m going to veto every single spending bill that crosses my desk.”
The debate came as Mr. Obama has pulled into a slight lead in polls this week.
In one testy exchange, Mr. McCain called out his opponent as someone who can’t figure out how to act in a bipartisan way because “it’s hard to reach across the aisle from that far to the left.”
“John mentioned me being wildly liberal,” Mr. Obama shot back. “Mostly that’s just me opposing George Bush’s wrong headed policies since I’ve been in Congress.”

Gov. Bill Richardson, D-N.M., a former United Nations ambassador, predicted that the debate would leave more voters than ever comfortable with the idea of Mr. Obama as commander-in-chief.

Sen. Lindsey Graham, R-S.C., a key McCain confidant, asserted that the Republican’s decades of experience provided an “ace in the hole”– and said the market turmoil made the stakes unusually high Friday.

Friday, September 26, 2008

It will be the first time Chinese yuhangyuan (astronauts) have ventured outside their spacecraft.

Three China astronauts braced for walk.

China's three astronauts have spent their first day in orbit preparing for the mission's spacewalk
.
A 42-year-old fighter pilot, Zhai Zhigang, is due to carry out the 20-minute manoeuvre at 1630 Beijing Time (0830 GMT) on Saturday.
It will be the first time Chinese yuhangyuan (astronauts) have ventured outside their spacecraft. Their Shenzhou VII capsule soared into orbit on a Long March II-F rocket from Jiuquan spaceport in north-west China. The rocket put the Shenzhou capsule in a near-circular orbit more than 300km above the Earth.

Mr Zhai is joined on the mission by two other "yuhangyuan" - Liu Boming and Jing Haipeng.
Zhang Jianqi, one of the chief engineers for China's space programme, said keeping three men in the spacecraft, and then sending one outside, would be a "big test".
"This is a big technological leap," he told state-run news agency Xinhua.
"The risks are quite high. Sending up three astronauts is a jump both in quantity and quality."
When Mr Zhai carries out his extra-vehicular activity (EVA), he is expected to wear a Chinese-made spacesuit thought to have cost between £5m and £20m ($10m-$40m).

China Space History Events
1958: Base for spaceflights built at Jiuquan, in Gobi desert
April 1970: China launches its first satellite into space
1990-2002: Shenzhou I-IV are launched to develop systems
Oct 2003: The first manned space mission launches on Shenzhou V
Oct 2005: The Shenzhou VI mission takes two men into space
Oct 2007: Chang'e-1 orbiter sent on unmanned mission to the Moon

The yuhanguan will be tethered to the capsule with a cable that provides him with life support and a communications link with the spacecraft.
His back-up, Mr Liu, will monitor the activity, presumably to reel the spacewalker back inside if there is an emergency.
Mr Zhai will retrieve an externally mounted experiment and oversee the release of a satellite.
At the end of the mission, the Shenzhou re-entry capsule will target a landing in north China's Inner Mongolia Autonomous Region.
China became only the third nation after the United States and Russia to independently put a man in space when Yang Liwei, another fighter pilot, went into orbit on the Shenzhou V mission in October 2003.
Two years later, Fei Junlong and Nie Haisheng completed a five-day flight on Shenzhou VI.
According to the Associated Press, China's official news agency posted an article on its website prior to the lift-off that was written as if Shenzhou VII had already been launched into space.
Please turn on JavaScript. Media requires JavaScript to play.
China's Shenzhou VII rocket blasts off
The article reportedly carried a date of 27 September and came complete with a dialogue between the astronauts.
Chinese media report that this latest mission is the "most critical step" in the country's "three-step" space programme.
These stages are: sending a human into orbit, docking spacecraft together to form a small laboratory and, ultimately, building a large space station.
The Shenzhou VIII and IX missions are expected to help set up a space laboratory complex in 2010.
China launched an unmanned Moon probe last year about one month after rival Japan blasted its own lunar orbiter into space.
Story from BBC NEWS:http://news.bbc.co.uk/go/pr/fr/-/2/hi/science/nature/7637818.stm

When China successfully launched its first manned space flight in October 2003, there were some differences of opinion in English-language reports about what to call the pilot, Colonel Yang Liwei.
Ever since the start of space travel we’ve had two words for a space traveller, cosmonaut from the old USSR and the more common US term astronaut. A third began to appear about 1999 in reference to the Chinese space programme: taikonaut, a cross-bred offspring of the Chinese term tai kong, space, with the -naut ending of the other terms (which derives from Greek nautes, a sailor). Taikonaut seems to have been invented by amateur space enthusiasts and taken up by journalists.
However, the usual Chinese term is yuhangyuan, which has been used for many years to refer to participants in the American and Russian space programmes. This has been borrowed by English-language newspapers in the last couple of months or so in reports of the Chinese project. It’s a transliteration of Chinese words that literally mean “universe travel worker”, an individual paid to go into space. Knowing that somehow takes the mystery out of it.
Since astronaut is available, why English-language writers are bothering with the Chinese word isn’t clear (especially when the China Daily and the South China Morning Post both use astronaut in their English-language reports). Perhaps it’s just the restless journalistic quest for novelty. If so, yuhangyuan is likely soon to vanish from English again.
[Many thanks to Martin Turner in Hong Kong for his help.]
As the countdown clock ticks away, best-guesses have set the Chinese launching of their first taikonaut, or yuhangyuan, into orbit on or around Oct. 15, 2003.
[International Herald Tribune, 10 Oct. 2003]
After the launch from the Jiuquan site in Gansu province, the Shenzhou is expected to make more than a dozen orbits of Earth, providing time for a possible spacewalk by the yuhangyuan who by then will not be feeling the weight of their 10kg spacesuits.
[The Guardian, 6 Oct. 2003]

Thursday, September 25, 2008

While the USa Presidential Campaign Gets Bogged Down in the Economy... We return to Spce this Week.


NASA’s Dirty Secret: Moon Dust
ScienceDaily (Sep. 24, 2008) — The Apollo Moon missions of 1969-1972 all share a dirty secret. “The major issue the Apollo astronauts pointed out was dust, dust, dust,” says Professor Larry Taylor, Director of the Planetary Geosciences Institute at the University of Tennessee. Fine as flour and rough as sandpaper, Moon dust caused ‘lunar hay fever,’ problems with space suits, and dust storms in the crew cabin upon returning to space.
Taylor and other scientists will present their research on lunar dust at the “Living on a Dusty Moon” session on Thursday, 9 October 2008, at the Joint Meeting of the Geological Society of America (GSA), Soil Science Society of America (SSSA), American Society of Agronomy (ASA), Crop Science Society of America (CSSA), and Gulf Coast Association of Geological Societies (GCAGS) in Houston, Texas, USA.* NASA will use these findings to plan a safer manned mission to the Moon in 2018. Taylor will also deliver a Pardee Keynote Session talk on Sunday, 5 October 2008 entitled “Formation and Evolution of Lunar Soil from An Apollo Perspective.”
The trouble with moon dust stems from the strange properties of lunar soil. The powdery grey dirt is formed by micrometeorite impacts which pulverize local rocks into fine particles. The energy from these collisions melts the dirt into vapor that cools and condenses on soil particles, coating them in a glassy shell.
These particles can wreak havoc on space suits and other equipment. During the Apollo 17 mission, for example, crewmembers Harrison “Jack” Schmitt and Gene Cernan had trouble moving their arms during moonwalks because dust had gummed up the joints. “The dust was so abrasive that it actually wore through three layers of Kevlar-like material on Jack’s boot,” Taylor says.
To make matters worse, lunar dust suffers from a terrible case of static cling. UV rays drive electrons out of lunar dust by day, while the solar wind bombards it with electrons by night.
Cleaning the resulting charged particles with wet-wipes only makes them cling harder to camera lenses and helmet visors. Mian Abbas of the National Space Science and Technology Center in Huntsville, Alabama, will discuss electrostatic charging on the moon and how dust circulates in lunar skies.
Luckily, lunar dust is also susceptible to magnets. Tiny specks of metallic iron (Fe0) are embedded in each dust particle’s glassy shell. Taylor has designed a magnetic filter to pull dust from the air, as well as a “dust sucker” that uses magnets in place of a vacuum.
He has also discovered that microwaves melt lunar soil in less time than it takes to boil a cup of tea. He envisions a vehicle that could microwave lunar surfaces into roads and landing pads as it drives, and a device to melt soil over lunar modules to provide insulation against space radiation. The heating process can also produce oxygen for breathing.
But the same specks of iron that could make moon dust manageable also pose a potential threat to human health, according to Bonnie Cooper at NASA’s Johnson Space Center. “Those tiny blebs of pure iron we see on the surface of lunar grains are likely to be released from the outside edges of the particle in the lungs and enter the bloodstream,” she says. Preliminary studies suggest that the inhalation of lunar dust may pose a health hazard, possibly including iron toxicity. Members of NASA’s Lunar Airborne Dust Toxicity Advisory Group, Cooper, Taylor, and colleagues are studying how moon dust affects the respiratory system. They plan to set a lunar dust exposure standard by 2010, in time for NASA engineers to design a safer and cleaner trip to the Moon.
*On 9 October, the following abstracts will be presented in the George R. Brown Convention Center, Room 310AD at the Joint Meeting:
Abstracts, Session 345: “Living on a Dusty Moon”
Abstract 345-1 (Taylor): “Formation of Lunar Dust: Unique Properties for a Human Outpost”
Abstract 345-9 (Cooper): “Physical and Biological Hazards of Lunar Dust and Their Impact on Habitat and Space Suit Design”

Wednesday, September 24, 2008

Japan and China Continue the Space Race without USA




Space Elevator: Most of a rocket’s fuel is spent blasting through Earth’s thick atmosphere and out of the planetâ€s strong gravitational field. But here’s an alternate strategy for getting payloads up to space: Construct a 62,000-mile-long cable jutting straight out from the equator, hold it in place with centripetal force, then lift satellites and spacecraft out of the atmosphere with a giant freight elevator.

One major hang-up: Cable strong enough to support the system does not yet exist, though it could be made from carbon nanotubes.


Shown above is “The Climber” which sill carry the payload. Photo by John Macneill

Japanese scientists are also attempting stepping into space - planning a lift that will take passengers 100,000 kilometres high. The project could see the realisation of a science fiction vision.The lift's carriages, which will themselves require new feats of engineering, would move up and down cables stronger and lighter than any material ever woven. They would be anchored to the ground and disappear into the sky, eventually reaching a satellite docking station orbiting above the Earth.Scientists hope that as well as carrying human passengers, the carriages could also haul huge, solar-powered generators that could power homes and businesses back on Earth. It could also remove barrels of nuclear waste, dumping them into space."Just like travelling abroad, anyone will be able to ride the elevator into space," Shuichi Ono, chairman of the Japan Space Elevator Association, told The Times.The project has sparked swift reaction from other quarters: several competing space lift projects are now believed to be under way, with NASA among those involved.An international conference is to be held in Japan in November, aiming to draw up a detailed timetable for the machine's production.It is thought the concept of the lift was first envisioned by the sci-fi writer Arthur C. Clarke, in his 1979 book The Fountains of Paradise.

Another great leap forward for China
Jon Swaine, London
September 24, 2008

Chinese astronaut Nie Haisheng is helped out of the re-entry capsule of China's second manned spacecraft, Shenzhou VI, in 2005. Photo: Reuters
CHINA'S ambitious space program is to take a giant leap this week when three astronauts blast off on a mission to take the nation's first space walk.
The Long March rocket, in position at the north-western Jiuquan launch centre, will lift the Shenzhou VII capsule into orbit late on Thursday for China's third manned flight.
According to government websites, Air Force Colonel Zhai Zhigang, 42, will make history when he steps out of the capsule on Friday or Saturday.
The 68-hour mission will bring China closer to its goal of building a small space laboratory, and later a space station, and will ramp up national pride after the Olympics and before National Day on October 1.
"My impression is that everything is going well in the final days before the launch," said Morris Jones, an Australian analyst who has closely studied China's space efforts.
"/>China became the third nation after the US and Russia to independently put a man in space when Yang Liwei, a fighter pilot, flew aboard the Shenzhou V in October 2003. In 2005, two astronauts manned the five-day Shenzhou VI mission.








Phoenix is turning over every rock, looking for water on Mars...


NASA's Phoenix Lander Might Peek Under A Rock
September 22, 2008 --- If the robotic arm on NASA's Phoenix Mars Lander can nudge a rock aside today, scientists on the Phoenix team would like to see what's underneath.
Engineers who develop commands for the robotic arm have prepared a plan to try displacing a rock on the north side of the lander. This rock, roughly the size and shape of a VHS videotape, is informally named "Headless."
"We don't know whether we can do this until we try," said Ashitey Trebi Ollennu, a robotics engineer at NASA's Jet Propulsion Laboratory, Pasadena, Calif. "The idea is to move the rock with minimum disturbance to the surface beneath it. You have to get under it enough to lift it as you push it and it doesn't just slip off the scoop."
The lander receives commands for the whole day in the morning, so there's no way to adjust in mid-move if the rock starts slipping. Phoenix took stereo-pair images of Headless to provide a detailed three-dimensional map of it for planning the arm's motions.
On Saturday, Sept. 20, the arm enlarged a trench close to Headless. Commands sent to Phoenix Sunday evening, Sept. 21, included a sequence of arm motions for today, intended to slide the rock into the trench.