Tuesday, August 30, 2011

Krystal is hard on my cars... second one she has wrecked. The retail book value is $7,100 . Think she totalled it?

Monday, August 22, 2011

Gov. Rick Perry is making a BIG Impression in Europe...

Can we agree that Texas Governor Rick Perry's presidential run is an unfolding three ring disaster disaster for the GOP?

Perry barely graduated from a minor Texas state college with a degree in animal husbandry, he has no graduate or professional school degree, and now he has serious ambitions to rewrite the United States Constitution and lead this nation?

If you're comfortable with that thought then you're comfortable with hastening the decline of the American century. You have reached the point where your reason has utterly capitulated to your ideology. You've become so used to extremists running the GOP show you can no longer see them.

You've gone nuts, in other words. Pardon me if I don't join you.

A five minute Google search will confirm what Karl Rove has been shouting about Rick Perry all week: if George W.Bush and Rick Perry were brothers then people would refer to Bush as 'the smart one.'

This is a man who last week hosted a high profile prayer rally featuring some of the most bigoted pastors in America prior to announcing his candidacy. If you're not aware Perry's 'prayer rally' was funded and co-sponsored by the American Family Association, whose spokesman Bryan Fischer claimed last week that the Nazi Party was founded by homosexuals in a Munich gay bar.

I'm not kidding, I couldn't make this stuff up, click this link and see for yourself.

Tidy isn't it: first the gays created the most evil far right fascist organization in human history, then they targeted themselves for extermination. Or something. Who the hell knows. I haven't been having seizures or talking in tongues so I have no idea where Fischer is getting his information from.

Giving a big public endorsement to these unhinged God botherers was not wise. Because in announcing their candidacy most politicians want to create a welcoming platform to illustrate they're part of the mainstream - but not Rick Perry. He chose instead to exclusively court his white, mostly southern evangelical base. Everyone outside the circle could take a hike.

Like Chairman of the Federal Reserve Ben Bernanke, for example. Last week Perry described him as 'treacherous' and 'treasonous' - and then he startled his hearers and the watching press corps by adding - 'I don't know what you all would do to him in Iowa, but we would treat him pretty ugly down in Texas.'

A treacherous, treasonous Jewish man who would come to harm if he ever visited Texas? Oh boy. Could we have that in the original German, Herr Perry? That's not colorful speaking, that's a despicable threat. It's also a measure of how far to the right the GOP has lunged in recent years that Perry's words were only middy challenged.

But it was Perry's ardent creationism that really made the headlines last week. During a campaign stop in South Carolina on Friday he told a young supporter: 'God is how we got here.'

'In Texas' he added, 'we teach both creationism and evolution in our public schools — because I figure you're smart enough to figure out which one is right.'

In fact Texas public schools do not teach creationism. Texas science standards do not call for teaching creationism in the classroom at all. How does the Governor of Texas not know the curriculum of the state's schools? Oh, right.

Another Perryesque eye-opener last week involved Bank of America Director of Public Policy James Mahoney. It was gratifying to see a beneficiary of bailout money assure Perry of his organizations financial support. Meanwhile Perry likes to talk up his job creation in Texas, which is largely due to stimulus money he said he wouldn't accept but did anyway.

But Texas actually leads the country in low-wage jobs. Texas has the highest percentage of people without health insurance. Texas has the highest rate of uninsured workers in the country at 27.4 percent. Texas leads America in dropouts.

Given these shocking findings, apparently Texas is doing a standup job messing with itself. For all his recent talk of secession from the Union, his state has done well by it.

But I think America can do without another Texas Governor in the White House for the time being. We've had one recently anyway and we all know how that worked out.


Saturday, August 20, 2011

What if our Congressmen and Voters had to sell their blood to pay the Interest n the National De, to pay for Our Wars, would they make better choices?

Let me tell you right now: I think donating plasma is an amazingly great thing to do. It’s a safe and easy way for people to help others while making some extra money. I’ve known poor college students that might have been homeless college students without plasma donation. And one time at the plasma center I met a single dad who told me he’d been giving plasma so he could put gifts for his daughter under the Christmas tree.

Without plasma donors like this, hemophiliacs, burn victims, and many other people in need could die waiting for essential transfusions.

This is a great example of a Win-Win situation. But I’m sure you have questions about the plasma donation process before you roll up your sleeve and let a phlebotomist take your precious plasma away. READ MORE ABOVE

Sunday, August 7, 2011

Gov. Rick Perry spoke and prayed at The Response in Houston, Texas

Rick Perry, whose Saturday prayer rally drew some 30,000 attendees, lamented a "nation in crisis" and faced protests outside Houston’s Reliant Stadium by gay rights activists who blasted the Texas governor for his event’s ties to the virulently antigay American Family Association.

“Lord, you are the source of every good thing,” Perry said in his 13-minute speech, which included Scripture passages and a prayer request for President Barack Obama. “You are our only hope, and we stand before you today in awe of your power and in gratitude for your blessings, and humility for our sins. Father, our heart breaks for America. We see discord at home. We see fear in the marketplace. We see anger in the halls of government, and as a nation we have forgotten who made us, who protects us, who blesses us, and for that we cry out for your forgiveness.”

GetEqual, which organized a Saturday protest, called the AFA-financed prayer rally "one more example of religion-based bigotry that helps ... send the message that discriminating against one particular group is okay."

“Our Governor invited, and therefore endorsed, groups to preach hate in our state,” said Michael Diviesti, GetEqual's Texas State Lead Organizer.

“The American Family Association and the Family Research Council empower the bullies that are driving our youth to suicide and the murderers who kill out of hatred and ignorance,” Diviesti said.

Read the Houston Chronicle report on The Response here.

Tuesday, August 2, 2011

It is complicated.....an Old Theory: Homo sapiens interbred with other hominins, has new supporting studies in science research.

Not so simple (Image: Richard Wilkinson)
Other Artwork by Richard Wilkinson
: http://www.richard-wilkinson.com/

Editorial: "Welcome to the complicated human family"

Welcome to the complicated human family
02 August 2011
New Scientist Magazine issue 2823. Subscribe and save

HOMO SAPIENS come in many shapes and sizes, yet we know one when we see one. If only classifying our extinct relatives were as simple.

With fossils in short supply, deciding where a species starts and ends is contentious. "Lumpers" tend to group fossils into relatively few species, while "splitters" see each morphological idiosyncrasy as potentially signifying a new species. Now the ability to sequence entire ancient genomes provides a new tool (see "Patchwork people: Our hybrid origins"). What will it reveal?

A previously unknown hominin has already been identified by its genes alone, and there could be more as further bones are probed. The result is likely to be a cornucopia of discoveries. We have already welcomed "hobbits" and Denisovans into our extended family. Who knows what other surprises lie in store.

Whether these are separate species is an open question, which the lumpers and splitters will continue to argue over. But instead of obsessing about how to chop up our family tree, ancient genomes may finally help us see human evolution for what it is: a dynamic process of constant interaction and change.

"Patchwork people: Our hybrid origins"
From issue 2823 of New Scientist magazine

In the past year, we've learned that early Homo sapiens interbred with other hominins – and it's forcing us to rethink our family tree

ONCE upon a time the human story seemed so simple. Between 5 and 7 million years ago, our ancestors split from those of chimpanzees. Since then, numerous human-like species have roamed the Earth, but we out-competed them all. Today we are the sole survivors.

Then came the news that these other hominins live on inside many of us. In a groundbreaking study of ancient DNA, a team led by Svante Pääbo at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, revealed that many people carry the genetic legacy of Neanderthals. Everyone of non-African descent can trace between 1 and 4 per cent of their genes directly back to our Homo cousins. These genes even turn up in people living in areas where no Neanderthal fossils have ever been found, such as China and Papua New Guinea.

The implication is clear: at some point in human history, populations that left Africa interbred with other ancient people. Homo sapiens is a hybrid (Science, vol 328, p 710).

That bombshell was dropped in May 2010. Seven months later, the team was at it again. This time they had sequenced DNA from a lone pinky finger bone, excavated from the Denisova cave in Siberia and dated to between 30,000 and 50,000 years old. Once again, they were able to unpick the full genome, revealing it to belong to a young woman from a previously unrecognised group of ancient hominins, which they named the Denisovans. And, once again, comparisons with modern humans showed that some of the ancient DNA lives on, comprising between 5 and 7 per cent of the genes of people from Melanesia, which includes Papua New Guinea, Fiji and nearby islands (Nature, vol 468, p 1053).

These two studies look set to spark a revolution. Pääbo and colleagues are the first to decipher entire genomes of ancient hominins. In doing so they bring a new approach to understanding human origins - one that has the potential to upend much of what we thought we knew about human evolution. Already, the results have settled a long-standing argument about whether early modern humans bred with other hominins as they spread around the world.

They also raise an intriguing possibility. The percentage of genes involved may be small, but with two positive results from two studies, it seems likely that further research will show genes from other extinct groups of hominins in modern humans too. In other words, it looks like we have a mosaic genome. Researchers are itching to get their hands on more hominin DNA to explore this possibility as well as other key questions about human origins. "Once, we just had fossils and we'd argue about what they really show," says John Hawks from the University of Wisconsin, Madison. "With DNA, you know when things are the same. It changes everything."

For a start, DNA analysis gives us a new way to identify the various groups of early human. Before now, they have always been defined on the basis of their bones, but the Denisovans are the first to reveal themselves by their genes alone. Analysis of their genome places them as cousins of the Neanderthals - their common ancestor split from our own ancestral line around 800,000 years ago, before dividing again around 640,000 years ago. But the paths of these three would cross again. "As populations increased in size and came into contact with one another, they started to interbreed," says Milford Wolpoff at the University of Michigan in Ann Arbor.

This interbreeding happened at least twice. DNA cannot show exactly when or where, but the most likely scenario is that when the ancestors of modern humans left Africa they bred with Neanderthals in the Middle East, around 60,000 years ago, picking up a small proportion of their genes before spreading throughout Europe and Asia. Then, in east Asia, they encountered Denisovans and repeated the same cycle of interbreeding and genetic acquisition, before colonising Melanesia 45,000 years ago. "Population mixture is not an exception in human evolution. It's perhaps the rule and it has been going on for a long period of human history," says geneticist David Reich at Harvard Medical School in Boston, who was involved in the studies.

These findings have catapulted geneticists into a controversial battle between two groups, each espousing a different story of human evolution. The first, supporters of the Out of Africa model, believe that all living humans trace their ancestry to a small African population that swept the world, replacing other species of early humans and consigning their genes to history. Their rivals, supporters of the so-called "multiregional model", see these prehistoric groups, scattered across Eurasia, as all part of a single evolving species that met and mated extensively over tens of thousands of years, ultimately giving rise to modern humans.

Neither fossils nor modern genomes could settle the debate, and for decades the same evidence would often be used to support both sides. "It was pretty polarised and personal at times," recalls Chris Stringer at the Natural History Museum in London, who championed the then-dominant Out of Africa model.

Breeding controversy
The ancient genome studies have reopened the debate. "It's nice to be on the right side of this," says Wolpoff, multiregionalism's fiercest champion. "The DNA we have shows three lineages of humans in the Pleistocene that can interbreed with each other. It's very much what we interpreted the fossils to mean." Stringer disagrees. "The implication [from the multiregional model] was that we would see Neanderthals gradually changing into modern humans," he says. "Instead, we see Neanderthals going up to around 30,000 or 40,000 years ago and then disappearing. They've passed some DNA on but that didn't change their evolutionary history."

Stringer also points out that only the most extreme versions of the Out of Africa model ruled out the possibility of sex between different groups. "I've never said there couldn't be interbreeding but I argued that it was trivial." He could still be right - it doesn't necessarily take a lot of sex for genes from a resident population to infiltrate the genomes of colonisers. When an incoming group mates with an established one, the genes they pick up quickly rise to prominence as their population grows. The truth is, we still don't know whether interbreeding was the norm for ancient hominins or something of a fringe activity. Reich and Pääbo are actively pursuing the problem by studying the genomes of modern people who carry Neanderthal DNA, but for now we have no answers.

Meanwhile, the sequencing of ancient DNA has also triggered a new wave of excitement among fossil hunters. The Denisovans are a particular source of inspiration because so far they are known only by one finger bone and a tooth found in the Denisova cave. Yet as their genes turn up in modern Melanesians, they must have spread across Asia. "We're starting to find fossils in southern China and south-east Asia that could well be connected to Denisovans," says Alan Cooper from the University of Adelaide in South Australia. "Things are afoot, and the ancient DNA provoked that."

In fact, both Stringer and Wolpoff believe it is likely that Denisovan fossils have already been found. Several skulls unearthed in China, for example, don't look like Neanderthals or modern humans, and could be Denisovans hidden in plain sight. They include remains like the Dali man found in central China, and Jinniushan man from the country's north-east. Analysis of DNA from fossils like these could help us work out when and where the Denisovans lived, and how this overlapped with the habitat of early modern humans.

While others concentrate on learning more about the Denisovans, Pääbo and Cooper have their sights set on the so-called "hobbit", a small hominin that lived on the Indonesian island of Flores from about 90,000 years ago. Since its discovery in 2004, there has been heated debate about how Homo floresiensis, as it is officially known, fits into our family tree. What makes it particularly intriguing is that despite it having a brain just a third the size of ours, it made tools, controlled fire and lived in much the same way as our direct ancestors, from whom it was geographically isolated. The hobbit genome doubtless has some stories to tell, but ancient DNA is easily degraded and contaminated and, so far, Pääbo and Cooper have been unable to obtain any from the fossils available. "We didn't get at the samples until every physical anthropologist in south-east Asia had handled the things," says Cooper. But he remains hopeful.

"Given that the hobbits survived until 12,000 years ago, it's just a question of finding the right specimen, one that has been preserved in clay or something similar." A single tooth was found more recently, and Cooper is keen to get his hands on it.

Back to our roots
Others would dearly love to sequence DNA from ancient African hominins. As the continent where humans evolved, Africa has a long history of diverse populations with lots of regional differences. "I think anything found in Africa has a chance of making things a lot more complicated," says Hawks. Until now, the various groups have been distinguished from one another by the morphology of fossils alone, but DNA analysis offers a new and more probing way of sorting out the relationships between them. That will be easier said than done, though. The problem is Africa's largely hot and humid climate - the worst conditions for preserving DNA.

Luckily there is another approach. "DNA can be dug up in a 40,000-year-old cave but it can also be passed down from parent to child," says Reich. Even without ancient genomes to hand, geneticists can look for signatures of interbreeding in the DNA of living people. They can hunt for parts of the genome that travel down the generations as a unit even though they are far apart; these could be heirlooms from other ancient hominins. They can also search for regions of the genome that seem older than their neighbours, which would hint at an origin that pre-dates the rise of modern humans.

Another approach is to identify parts of the genome that are considerably more diverse in people living in one part of the world than another. Rasmus Nielson at the University of California, Berkeley, did exactly that, comparing the DNA of people living in Africa with those living elsewhere and, without any ancient DNA, identified 13 sections of DNA in humans of non-African descent that could have come from Neanderthals. Sequencing of the Neanderthal genome confirmed that 10 of these predictions were right.

"The trick is to sequence the genomes of a diverse range of people from all across the world," says Reich. This work is already under way. An international consortium called the 1000 Genomes Project is currently sequencing genomes from populations that have been ignored by previous studies, including some in Africa, the Americas and the Indian subcontinent. These diverse genomes could be a source of important details about our history.

The prospects look promising. Tantalising hints that other extinct hominins have left echoes in many of our genomes have already been found. For example, many European and Asian people have a version of a gene called microcephalin, involved in brain development, which was thought to be inherited from Neanderthals. However, none of the three female Neanderthals that Pääbo and Reich analysed carried this variant, so either it was rare among Neanderthals or we acquired it from another hominin. Then there is the study by Jeffrey Wall from the University of Southern California, Los Angeles, which estimated that up to 14 per cent of Eurasian genomes could be heirlooms from ancient hominin groups. Neanderthals only contributed between 1 and 4 per cent, so who did the rest come from?

These approaches can tell us a lot about how much interbreeding early humans got up to, but they have limits. They rely on mathematical models that make several assumptions about how genes change over time. If these assumptions are wrong, the studies could detect phantom signs of mixed DNA, where none exists. "In this context, it is very useful to have an ancient genome to directly test these predictions," says Reich. The ancient DNA acts like a cheat-sheet, allowing scientists to run their models, check their "answers", and refine their methods. Ultimately, it was DNA that sealed the case that early humans interbred with other hominins, and we need more of it to really understand the mosaic nature of human evolution.

It must only be a matter of time. Fossil hunters are starting to handle their finds with the care of crime-scene analysts. "Everyone now treats new material as if it had DNA in it," says Wolpoff. "There are a lot of people who would like to have the next specimen that we get ancient DNA out of. Everybody knows the payoff is good. I think we're at the very beginning of the information explosion."

Rebuilding ancient genomes
The sequencing of ancient DNA has been a massive technical achievement. That's because DNA degrades with age, especially in hot and humid conditions. Even when it is present, it is usually swamped by genetic material from bacteria and fungi that have infiltrated the sample while it lay in the ground.

Working in a clean room to avoid contamination from their own DNA, researchers remove these unwanted sequences using enzymes. They then isolate the tiny fragments of ancient DNA, amplify them and use a computer to pinpoint overlapping segments so that they can stitch the genome back together. In this way, a team led by Svante Pääbo from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, was able to sequence 40,000-year-old DNA to get rough drafts of both the Neanderthal and Denisovan genomes.

To find out whether these two early hominins interbred with early modern humans, their genomes were compared with those of modern humans. Because of our common ancestry we share the vast majority of our genes with these groups, but the differences are telling. Pääbo's team focused on "single nucleotide polymorphisms", or SNPs, which are sites on the genome that vary from person to person by a single DNA "letter". Neanderthals share as many SNPs with Europeans as they do with Asians, but they share fewer with Africans. That makes them genetically closer to those living outside of Africa than those living in the continent.

The team also found that Denisovans share the same number of SNPs with almost all non-Africans, but they share even more with Melanesians. These small differences showed that Neanderthal DNA entered the modern human genome after Homo sapiens left Africa, and that Denisovan DNA came in after the Melanesians split from the rest of Asia.

The next step is to discover what these ancient genes do. "It's possible that early modern humans could have used the Neanderthal or Denisovan genetic material to adapt to their environment," says David Reich from Harvard Medical School in Boston. Indeed, the most recent studies indicate that interbreeding allowed early humans to acquire genes that helped protect them against local diseases as they migrated across the globe (New Scientist, 18 June 2011, p 11).

Just another promiscuous primate?
The animal world is rife with examples of incoming migrants replacing resident populations. Mammoths, cave bears, bison and others all show a similar pattern of migration and replacement to the one that characterises the spread of early modern humans across Eurasia. Whether these other animals inbred with resident populations or simply out-competed them is another matter - one that will only be resolved when their genomes are scrutinised.

However, we do know that hybridisation is fairly common in the natural world. For example, the surprising lack of genetic diversity among Old World monkeys suggests that as they evolved, many subspecies and species mated with one another to produce a complex tangle of hybrid lineages. "When species meet, they do have sex with each other," says Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. So perhaps we should not be surprised to find that early humans mated with individuals from other hominin groups that they came across, including Neanderthals and Denisovans.

Nevertheless, studies of ancient genomes may still reveal that early humans were more inclined to hybridise than other species. One underlying reason might be that human behaviour is driven by culture as well as biology. "Most cultures require you to seek mates someplace else: get your mates from another village, get your mates from the guys across the river," says Milford Wolpoff at the University of Michigan in Ann Arbor. "And that leads to a level of mixture that other species may not have. It remains to be seen whether we're one of many cases or whether we're special."

Ed Yong is a freelance writer based in London